Three new PhDs awarded to young researchers trained within GLYCOPHARM


Joint Publications

Authored by members of two or more GLYCOPHARM groups

  1. Bartoloni M, Dominguez BE, Dragoni E, Richichi B, Fragai M, André S, Gabius H-J, Ardá A, Luchinat C, Jiménez-Barbero J, Nativi C (2013) Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins, Chemistry 19:1896-1902
  2. Fik Z, Valach J, Chovanec M, Mazanek J, Kodet R, Kodet O, Tachezy R, Foltynova E, André S, Kaltner H, Gabius H-J, Smetana K Jr (2013) Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas, J Oral Pathol Med 42:166-173
  3. Ardá A, Blasco P, Varon Silva D, Schubert V, André S, Bruix M, Cañada FJ, Gabius H-J, Unverzagt C, Jiménez-Barbero J (2013) Molecular recognition of complex-type biantennary N-glycans by protein receptors: a three-dimensional view on epitope selection by NMR, J Am Chem Soc 135:2667-2675
  4. Smetana K Jr, André S, Kaltner H, Kopitz J, Gabius H-J (2013) Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target, Expert Opin Ther Targets 17:379-392
  5. Kopitz J, Fik Z, André S, Smetana K Jr, Gabius H-J (2013) Single-site mutational engineering and following monoPEGylation of the human lectin galectin-2: effects on ligand binding, functional aspects, and clearance from serum, Mol Pharm 10:2054-2061
  6. Ruiz FM, Fernández IS, López-Merino L, Lagartera L, Kaltner H, Menéndez M, André S, Solís D, Gabius H-J, Romero A (2013) Fine-tuning of prototype chicken galectins: structure of CG-2 and structure-activity correlations, Acta Crystallogr D Biol Crystallogr 69:1665-1676
  7. Vidal P, Roldós V, Fernández-Alonso MC, Vauzeilles B, Bleriot Y, Cañada FJ, André S, Gabius H-J, Jiménez-Barbero J, Espinosa JF, Martín-Santamaría S (2013) Conformational Selection in Glycomimetics: Human Galectin-1 Only Recognizes syn-Psi-Type Conformations of beta-1,3-Linked Lactose and Its C-Glycosyl Derivative, Chemistry 19:14581-14590
  8. Canales A, Mallagaray A, Pérez-Castells J, Boos I, Unverzagt C, André S, Gabius H-J, Cañada FJ, Jiménez-Barbero J (2013) Breaking pseudo-symmetry in multiantennary complex N-glycans using lanthanide-binding tags and NMR pseudo-contact shifts, Angew Chem Int Ed Engl 52:13789-13793
  9. Berbis MA, André S, Cañada FJ, Pipkorn R, Ippel H, Mayo KH, Kubler D, Gabius H-J, Jiménez-Barbero J (2014) Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner, Biochem Biophys Res Commun 443:126-131
  10. Ippel H, Miller MC, Berbis MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius H-J, Jiménez-Barbero J, Mayo KH (2014) 1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3, Biomol NMR Assign Feb 7
  11. Ruiz FM, Scholz BA, Buzamet E, Kopitz J, André S, Menéndez M, Romero A, Solís D, Gabius H-J (2014) Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells, FEBS J 281:1446-1464
  12. Canales A, Mallagaray A, Berbis MA, Navarro-Vázquez A, Domínguez G, Cañada FJ, André S, Gabius H-J, Pérez-Castells J, Jiménez-Barbero J (2014) Lanthanide-chelating carbohydrate conjugates are useful tools to characterize carbohydrate conformation in solution and sensitive sensors to detect carbohydrate-protein interactions, J Am Chem Soc 136:8011-8017
  13. Mifkova A, Kodet O, Szabo P, Kucera J, Dvorankova B, André S, Koripelly G, Gabius H-J, Lehn JM, Smetana K Jr (2014) Synthetic polyamine BPA-C8 inhibits TGF-beta1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro, Chembiochem 15:1465-1470
  14. Perzelova V, Varinska L, Dvorankova B, Szabo P, Spurny P, Valach J, Mojzis J, André S, Gabius H-J, Smetana K Jr, Gal P (2014) Extracellular Matrix of Galectin-1-exposed Dermal and Tumor-associated Fibroblasts Favors Growth of Human Umbilical Vein Endothelial Cells In Vitro: A Short Report, Anticancer Res 34:3991-3996
  15. Kopitz J, Vertesy S, Andre S, Fiedler S, Schnolzer M, Gabius H-J (2014) Human chimera-type galectin-3: Defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in neuroblastoma cell growth regulation, Biochimie 104:90-99
  16. Xu B, Unione L, Sardinha J, Wu S, Ethève-Quelquejeu M, Pilar Rauter A, Blériot Y, Zhang Y, Martín-Santamaría S, Díaz D, Jiménez-Barbero J, Sollogoub M (2014) gem-Difluorocarbadisaccharides: restoring the exo-anomeric effect, Angew Chem Int Ed Engl 53:9597-602
  17. Katzenmaier EM, André S, Kopitz J, Gabius H-J (2014) Impact of sodium butyrate on the network of adhesion/growth-regulatory galectins in human colon cancer in vitro, Anticancer Res 34:5429-5438
  18. André S, Singh T, Lacal JC, Smetana K Jr, Gabius H-J (2014) Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro, Folia Biol (Praha) 60:95-107
  19. Marcelo F, García-Martín F, Matsushita T, Sardinha J, Coelho H, Oude-Vrielink A, Koller C, André S, Cabrita EJ, Gabius H-J, Nishimura S, Jiménez-Barbero J, Cañada FJ (2014) Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin, Chemistry 20:16147-55. DOI: 10.1002/chem.201404566
  20. Solís D, Bovin NV, Davis AP, Jiménez-Barbero J, Romero A, Roy R, Smetana K Jr, Gabius H-J (2015) A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code, Biochim Biophys Acta 1850:186–235. DOI: 10.1016/j.bbagen.2014.03.016
  21. Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamaría S (2015) Chemistry of lipid A: at the heart of innate immunity, Chemistry 21:500-19. DOI: 10.1002/chem.201403923
  22. Flores-Ibarra A, Ruiz FM, Vértesy S, André S, Gabius H-J, Romero A (2015) Preliminary X-ray crystallographic analysis of an engineered variant of human chimera-type galectin-3 with a shortened N-terminal domain, Acta crystallographica. Section F, Structural biology communications 71:184-8. DOI: 10.1107/S2053230X15000023
  23. Smetana K, Szabo P, Gal P, André S, Gabius H-J, Kodet O, Dvořánková B (2015) Emerging role of tissue lectins as microenvironmental effectors in tumors and wounds, Histol Histopathol 30:293-309. DOI: 10.14670/HH-30.293
  24. van de Weerd R, Berbís MA, Sparrius M, Maaskant JJ, Boot M, Paauw NJ, de Vries N, Boon L, Baba O, Cañada FJ, Geurtsen J, Jiménez-Barbero J, Appelmelk BJ (2015) A murine monoclonal antibody to glycogen: characterization of epitope-fine specificity by Saturation Transfer Difference (STD) NMR Spectroscopy and its use in mycobacterial capsular alpha-glucan research, Chembiochem 16:977-89. DOI: 10.1002/cbic.201402713
  25. Ippel H, Miller MC, Berbís MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius H-J, Jiménez-Barbero J, Mayo KH (2015) 1-H, 13-C, and 15-N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 Kda human chimera-type galectin-3, Biomolecular NMR Assignments 9:59-63. DOI: 10.1007/s12104-014-9545-3
  26. Vértesy S, Michalak M, Miller MC, Schnölzer M, André S, Kopitz J, Mayo KH, Gabius H-J (2015) Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence, Protein Eng Des Sel 28:199-210. DOI: 10.1093/protein/gzv014
  27. Unione L, Xu B, Díaz D, Martín-Santamaría S, Poveda A, Sardinha J, Rauter AP, Bleriot Y, Zhang Y, Cañada FJ, Sollogoub M, Jiménez-Barbero J (2015) Conformational plasticity in glycomimetics: Fluorocarbamethyl-L-idopyranosides mimic the intrinsic dynamic behaviour of natural idose rings, Chemistry 21:10513-21. DOI: 10.1002/chem.201501249
  28. Gabius H-J, Kaltner H, Kopitz J, André S (2015) The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function, Trends Biochem Sci 40:360-76. DOI: 10.1016/j.tibs.2015.03.013
  29. Calle LP, Echeverria B, Franconetti A, Serna S, Fernández-Alonso MC, Diercks T, Cañada FJ, Ardá A, Reichardt NC, Jiménez-Barbero J (2015) Monitoring glycan-protein interactions by NMR spectroscopic analysis: A simple chemical tag that mimics natural CH-pi interactions, Chemistry 21: 11408-16. DOI: 10.1002/chem.201501248
  30. Rodríguez MC, Yegorova S, Pitteloud JP, Chavaroche AE, André S, Ardá A, Minond D, Jiménez-Barbero J, Gabius H-J, Cudic M (2015) Thermodynamic switch in binding of adhesion/growth regulatory human galectin-3 to tumor-associated TF antigen (CD176) and MUC1 glycopeptides, Biochemistry 54:4462-74. DOI: 10.1021/acs.biochem.5b00555
  31. Ruiz FM, Gilles U, Lindner I, André S, Romero A, Reusch D, Gabius H-J (2015)  Combining crystallography and hydrogen-deuterium exchange to study galectin-ligand complexes, Chemistry 21:13558-68. DOI: 10.1002/chem.201501961
  32. Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius H-J, Al-Hashimi HM, Markovit DM (2015) Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity, Cell 163: 746-58. DOI: 10.1016/j.cell.2015.09.056
  33. Ardá A, Bosco R, Sastre J, Cañada FJ, Sabine A, Gabius H-J, Richichi B, Jiménez-Barbero J, Nativi C (2015) Structural insights into the binding of sugar receptors (lectins) to a synthetic tricyclic Tn mimetic and its glycopeptide version, European J Org Chem 2015:6823-31. DOI: 10.1002/ejoc.201500874
  34. Coelho H, Matsushita T, Artigas G, Hinou H, Cañada FJ, Lo-Man R, Leclerc C, Cabrita EJ, Jiménez-Barbero J, Nishimura S, García-Martín F, Marcelo F (2015) The Quest for anticancer vaccines: Deciphering the fine-epitope specificity of cancer-related monoclonal antibodies by combining microarray screening and saturation transfer difference NMR, J Am Chem Soc 137:12438-41. DOI: 10.1021/jacs.5b06787
  35. Ribeiro JP, Diercks T, Jiménez-Barbero J, André S, Gabius H-J, Cañada FJ (2015) Fluorinated carbohydrates as lectin ligands: (19)F-based direct STD monitoring for detection of anomeric selectivity, Biomolecules 5:3177-92. DOI: 10.3390/biom5043177
  36. Peržel’ová V, Sabol F, Vasilenko T, Novotný M, Kováč I, Slezák M, Ďurkáč J, Hollý M, Pilátová M, Szabo P, Varinská L, Čriepoková Z, Kučera T, Kaltner H, André S, Gabius H-J, Mučaji P, Smetana K, Gál P (2016) Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing, Int J Mol Med 37:21-8. DOI: 10.3892/ijmm.2015.2351
  37. Ippel H, Miller MC, Vértesy S, Zheng Y, Cañada FJ, Suylen D, Umemoto K, Romanò C, Hackeng T, Tai G, Leffler H, Kopitz J, André S, Kübler D, Jiménez-Barbero J, Oscarson S, Gabius H-J, Mayo K-H (2016) Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR, Glycobiology 26:888-903. DOI: 10.1093/glycob/cww021
  38. Smorodinova N, Kaltner H, Jirsová K, Hrdličková-Cela E, André S, Kučera T, Smetana K Jr, Gabius H-J (2016) Regulatory impact of amniotic membrane transplantation on presence of adhesion/growth-regulatory galectins-1 and -7 in corneal explants from Acanthamoeba keratitis patients: Clinical note, Curr Eye Res 41:740-6. DOI: 10.3109/02713683.2015.1061022
  39. García Caballero G, Kaltner H, Michalak M, Shilova N, Yegres M, André S, Ludwig AK, Manning JC, Schmidt S, Schnölzer M, Bovin NV, Reusch D, Kopitz J, Gabius H-J (2016) Chicken GRIFIN: A homodimeric member of the galectin network with canonical properties and a unique expression profile, Biochimie 128-129:34-47. DOI: 10.1016/j.biochi.2016.06.001
  40. García Caballero G, Flores-Ibarra A, Michalak M, Khasbiullina N, Bovin NV, André S, Manning JC, Vértesy S, Ruiz FM, Kaltner H, Kopitz J, Romero A, Gabius H-J (2016) Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure, Biochim Biophys Acta 1860:2285-97. DOI: 10.1016/j.bbagen.2016.06.001
  41. Lacetera A, Galante S, Jiménez-Barbero J, Martín-Santamaría S (2016) Glycans in medicinal chemistry, In, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2016, B978-0-12-409547-2.11712-3 (Ed. Reedijk J), Elsevier.
  42. Ludwig AK, Vértesy S, Michalak M, Manning JC, André S, Kübler D, Kopitz J, Kaltner H, Gabius H-J (2016) Playing modular puzzle with adhesion/growth-regulatory galectins: Design and testing of a hybrid to unravel structure-activity relationships, Protein Pept Lett 23:1003-12. DOI: 10.2174/0929866523666160930123421
  43. Michalak M, Warnken U, André S, Schnölzer M, Gabius HJ, Kopitz J. Detection of proteome changes in human colon cancer induced by cell surface binding of growth-inhibitory human galectin-4 using quantitative SILAC-based proteomics, J Proteome Res 15:4412-22. DOI: 10.1021/acs.jproteome.6b00473
  44. Artigas G, Hinou H, Garcia-Martin F, Gabius HJ, Nishimura SI (2016) Synthetic mucin-like glycopeptides as versatile tools to measure effects of glycan structure/density/position on the interaction with adhesion/growth-regulatory galectins in arrays, Chem Asian J Epub Nov 21. DOI: 10.1002/asia.201601420
  45. Manning JC, Romero A, Habermann FA, García Caballero G, Kaltner H, Gabius HJ (2017) Lectins: a primer for histochemists and cell biologists, Histochem Cell Biol 147:199-222. DOI: 10.1007/s00418-016-1524-6

Individual Publications

  1. Toegel S, Bieder D, André S, Altmann F, Walzer SM, Kaltner H, Hofstaetter JG, Windhager R, Gabius H-J (2013) Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein, Arthritis Res Ther 15:R147
  2. Calle L, Roldós V, Cañada FJ, Uhrig ML, Cagnoni AJ, Manzano VE, Varela O, Jiménez-Barbero J (2013) Escherichia coli beta-galactosidase inhibitors through modifications at the aglyconic moiety: experimental evidence of conformational distortion in the molecular recognition process, Chemistry 19:4262-4270
  3. Murphy PV, André S, Gabius H-J (2013) The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity, Molecules 18:4026-4053
  4. Percec V, Leowanawat P, Sun HJ, Kulikov O, Nusbaum CD, Tran TM, Bertin A, Wilson DA, Peterca M, Zhang S, Kamat NP, Vargo K, Moock D, Johnston ED, Hammer DA, Pochan DJ, Chen Y, Chabre YM, Shiao TC, Bergeron-Brlek M, André S, Roy R, Gabius H-J, Heiney PA (2013) Modular synthesis of amphiphilic janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins, J Am Chem Soc 135:9055-9077
  5. Dawson H, André S, Karamitopoulou E, Zlobec I, Gabius H-J (2013) The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity, Anticancer Res 33:3053-3059
  6. Kaltner H, Raschta AS, Manning JC, Gabius H-J (2013) Copy-number variation of functional galectin genes: studying animal galectin-7 (p53-induced gene 1 in man) and tandem-repeat-type galectins-4 and -9, Glycobiology 23:1152-1163
  7. Knirel YA, Gabius H-J, Blixt O, Rapoport EM, Khasbiullina NR, Shilova NV, Bovin NV (2014) Human tandem-repeat-type galectins bind bacterial non-betaGal polysaccharides, Glycoconj J 31:7-12
  8. Gabius H-J, Kayser K (2014) Introduction to glycopathology: the concept, the tools and the perspectives, Diagn Pathol 9:4
  9. André S, Wang GN, Gabius H-J, Murphy PV (2014) Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4), Carbohydr Res 389:25-38
  10. Unione L, Galante S, Díaz D, Cañada FJ,  Jiménez-Barbero J (2014) NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions, Med. Chem. Commun 5:1280-1289
  11. Zhang S, Moussodia RO, Sun HJ, Leowanawat P, Muncan A, Nusbaum CD, Chelling KM, Heiney PA, Klein ML, André S, Roy R, Gabius H-J, Percec V (2014) Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers, Angew Chem Int Ed Engl 53:10899-10903
  12. Toegel S, Bieder D, André S, Kayser K, Walzer SM, Hobusch G, Windhager R, Gabius H-J (2014) Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration, Histochem Cell Biol  142:373-388
  13. Faria-Oliveira F, Carvalho J, Belmiro C, Martínez-Gomariz M, Hernaez M, Pavão M, Gil C, Lucas C, Ferreira C (2014) Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics, BMC Microbiol 14:244
  14. Campanero-Rhodes MA, Llobet E, Bengoechea JA, Solís D (2015) Bacteria microarrays as sensitive tools for exploring pathogen surface epitopes and recognition by host receptors, RSC Advances 5:7173-81. DOI: 10.1039/c4ra14570d
  15. Rauthu SR, Shiao TC, André S, Miller MC, Madej E, Mayo KH, Gabius H-J, Roy R (2015) Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: Synthesis, activity screening, and HSQC-based NMR analysis, Chembiochem 16:126-39. DOI: 10.1002/cbic.201402474
  16. André S, Kaltner H, Manning JC, Murphy PV, Gabius H-J (2015) Lectins: getting familiar with translators of the sugar code, Molecules 20:1788-823. DOI: 10.3390/molecules20021788
  17. André S, Kövér KE, Gabius H-J, Szilágyi L (2015) Thio- and selenoglycosides as ligands for biomedically relevant lectins: Valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides, Bioorg Med Chem Lett 25:931-5. DOI: 10.1016/j.bmcl.2014.12.049
  18. Zhang S, Moussodia RO, Murzeau C, Sun HJ, Klein ML, Vértesy S, André S, Roy R, Gabius H-J, Percec V (2015) Dissecting molecular aspects of cell interactions using glycodendrimersomes with programmable glycan presentation and engineered human lectins. Angew Chem Int Ed Engl 54:4036-40. DOI: 10.1002/anie.201410882.
  19. André S, O'Sullivan S, Koller C, Murphy PV, Gabius H-J (2015) Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins, Org Biomol Chem 3:4190-203. DOI: 10.1039/c5ob00048c
  20. Zhang S, Moussodia RO, Vertesy S, André S, Klein ML, Gabius H-J, Percec V (2015) Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface, Proc Natl Acad Sci U S A 112:5585-90. DOI: 10.1073/pnas.1506220112
  21. Dvořánková B, Smetana K, Rihova B, Kucera J, Mateu R, Szabo P (2015) Cancer-associated fibroblasts are not formed from cancer cells by epithelial-to-mesenchymal transition in nu/nu mice, Histochem Cell Biol 143:463-9. DOI: 10.1007/s00418-014-1293-z
  22. Faria-Oliveira F, Carvalho J, Belmiro CLR, Ramalho G, Pavão M, Lucas C, Ferreira C (2015) Elemental biochemical analysis of the polysaccharides in the extracellular matrix of the yeast Saccharomyces cerevisiae, J Basic Microbiol 55:685-94. DOI: 10.1002/jobm.201400781
  23. Rapoport EM, Matveeva VK, Kaltner H, André S, Vokhmyanina OA, Pazynina GV, Severov VV, Ryzhov IM, Korchagina EY, Belyanchikov IM, Gabius H-J, Bovin NV (2015) Comparative lectinology: Delineating glycan-specificity profiles of the chicken galectins using neoglycoconjugates in a cell assay, Glycobiology  25:726-34. DOI: 10.1093/glycob/cwv012
  24. Majewski J, André S, Jones E, Chi E, Gabius H-J (2015) X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE-GM1 lipid monolayer at an air/water interface, Biochemistry (Mosc) 80:943-56. DOI: 10.1134/S0006297915070135.
  25. Gabius H-J (2015) The magic of the sugar code, Trends Biochem Sci 40:341. DOI: 10.1016/j.tibs.2015.04.003
  26. André S, Classen B, Gabius H-J (2015) Studies on unprocessed and acid-treated arabinogalactan from larch as an inhibitor of glycan binding of a plant toxin and biomedically relevant human lectins, Planta Med 81: 1146-53. DOI: 10.1055/s-0035-1546113
  27. Papini AM, König E (2015) Novel diagnostic tools and solutions for multiple sclerosis treatment: A patent review (2009 - 2014), Expert Opin Ther Pat 25:873-84. DOI: 10.1517/13543776.2015.1043267.
  28. Di Lorenzo F, Kubik L, Oblak A, Lore NI, Cigana C, Lanzetta R, Parrilli M, Hamad MA, De Soyza A, Silipo A, Jerala R, Bragonzi A, Valvano MA, Martín-Santamaría S, Molinaro A (2015) Activation of human Toll-like receptor 4 (TLR4)·myeloid differentiation factor 2 (MD-2) by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia, J Biol Chem 290:21305-19. DOI: 10.1074/jbc.M115.649087
  29. André S, O’Sullivan S, Gabius H-J, Murphy PV (2015) Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity, Tetrahedron 71:6867-80. DOI: 10.1016/j.tet.2015.07.020
  30. Glinschert A, Oscarson S (2015) Synthesis of four (4"-, 2"-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-D-Glcp-(1 → 3)-α-D-Manp-(1 → 2)-α-D-ManpOMe recognized by calreticulin/calnexin, Carbohydr Res 414: 65-71. DOI: 10.1016/j.carres.2015.07.006
  31. Zhang S, Xiao Q, Sherman SE, Muncan A, Ramos Vicente AD, Wang Z, Hammer DA, Williams D, Chen Y, Pochan DJ, Vértesy S, André S, Klein ML, Gabius H-J, Percec V (2015) Glycodendrimersomes from sequence-defined Janus glycodendrimers reveal high activity and sensor capacity for the agglutination by natural variants of human lectins, J Am Chem Soc 137:13334-44. DOI: 10.1021/jacs.5b08844
  32. Alves S, Castro L, Fernandes M, Castro P, Priault M, Chaves S, Moyer M, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A (2015) Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy, Oncotarget 6:30787-802. DOI: 10.18632/oncotarget.5021
  33. Faria-Oliveira F, Carvalho J, Ferreira C, Hernáez ML, Gil C, Lucas C (2015) Quantitative differential proteomics of yeast extracellular matrix: there is more to it than meets the eye, BMC Microbiol 15:271. DOI: 10.1186/s12866-015-0550-1
  34. Kaltner H, Singh T, Manning JC, Raschta AS, André S, Sinowatz F, Gabius H-J (2015) Network monitoring of adhesion/growth-regulatory galectins: Localization of the five canonical chicken proteins in embryonic and maturing bone and cartilage and their introduction as histochemical tools, Anat Rec (Hoboken) 298:2051-70. DOI: 10.1002/ar.23265
  35. Wu G, Lu ZH, André S, Gabius H-J, Ledeen RW (2016) Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca2+ influx, J Neurochem 136:550-63. DOI: 10.1111/jnc.13418
  36. André S, Kaltner H, Kayser K, Murphy PV, Gabius H-J (2016) Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context, Histochem Cell Biol 145:185-99. DOI: 10.1007/s00418-015-1383-6
  37. Xiao Q, Zhang S, Wang Z, Sherman SE, Moussodia RO, Peterca M, Muncan A, Williams DR, Hammer DA, Vértesy S, André S, Gabius H-J, Klein ML, Percec V (2016) Onion-like glycodendrimersomes from sequence-defined Janus glycodendrimers and influence of architecture on reactivity to a lectin, Proc Natl Acad Sci U S A 113:1162-7. DOI: 10.1073/pnas.1524976113
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